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This condition causes reduced blood flow to the legs, leading to pain while walking. [1] It is taken by mouth Pharmacokinetic and Pharmacodynamic Drug-Drug Interactions, Lovastatin). Consumer; Professional; Note: This document contains side effect information about cilostazol. Pletal may also be used for purposes not listed in this medication guide Cilostazol did not inhibit the pharmacologic effects (PT, aPTT, bleeding time, or platelet aggregation) of R- and S-warfarin after a single 25-mg dose of warfarin. The information eHealthMe analyzes includes: With medical big data and AI algorithms, eHealthMe enables everyone to run phase IV clinical trial to detect adverse drug outcomes and monitor effectiveness. Applies to cilostazol: oral tablets. Avoid or Use Alternate Drug Recommended dosage. Cilostazol, sold under the brand name Pletal among others, is a medication used to help the symptoms of intermittent claudication in peripheral vascular disease. Summary: We study 6,278 Pletal users. [2] It may also be used to prevent stroke. This medicine improves your ability to walk longer distances without pain. Pletal is absorbed after oral administration Cilostazol did not inhibit the pharmacologic effects (PT, aPTT, bleeding time, or platelet aggregation) of R-and S-warfarin after a single 25-mg dose of warfarin. Some of the dosage forms listed on this page may not apply to the brand name Pletal. The effect of concomitant multiple dosing of warfarin and Pletal on the pharmacodynamics of both drugs is unknown. [1] If no improvement is seen after 3 months, stopping the medication is reasonable. PLETAL is absorbed after oral administration Decrease cilostazol dose by 50%; 3,4-dehydrocilostazol, an active metabolite, increased by 69% as a result of omeprazole inhibition of CYP2C19. Patients may respond as early as 2 to 4 weeks after the initiation of therapy, but treatment for up to 12 weeks may be needed before a beneficial effect is experienced. Pletal is used to treat the symptoms of intermittent claudication. Fexinidazole will increase the level or effect of cilostazol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Our original studies have been referenced on 600+ peer-reviewed medical publications including The Lancet. The effect of concomitant multiple dosing of warfarin and PLETAL on the pharmacodynamics of both drugs is unknown. The recommended dosage of PLETAL is 100 mg twice daily taken at least half an hour before or two hours after breakfast and dinner.

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